Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC3146253 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Liu Su S Lee Yi-Fen YF Chou Samuel S Uno Hideo H Li Gonghui G Brookes Paul P Massett Michael P MP Wu Qiao Q Chen Lu-Min LM Chang Chawnshang C
Molecular endocrinology (Baltimore, Md.) 20110526 8
The estimated incidence of mitochondrial diseases in humans is approximately 1:5000 to 1:10,000, whereas the molecular mechanisms for more than 50% of human mitochondrial disease cases still remain unclear. Here we report that mice lacking testicular nuclear receptor 4 (TR4(-/-)) suffered mitochondrial myopathy, and histological examination of TR4(-/-) soleus muscle revealed abnormal mitochondrial accumulation. In addition, increased serum lactate levels, decreased mitochondrial ATP production, ...[more]