Associations of cardiovascular risk factors with two surrogate markers of subclinical atherosclerosis: endothelial function and carotid intima media thickness.

ABSTRACT:

Objective

Endothelial function and carotid intima media thickness (cIMT) were investigated in a cohort of 54 healthy adults without known cardiovascular disease.

Methods

Pulse wave amplitude was determined with peripheral arterial tonometry (PAT) to obtain the reactive hyperemia (RH)-PAT ratio. Ultrasound was used to determine cIMT.

Results

cIMT and RH-PAT were significantly associated (rho=-0.35, P=0.02) in univariate analysis. RH-PAT was significantly associated with age, triglycerides, fasting glucose, HDL, WHR, waist circumference and VAT. cIMT was associated with age, smoking history, fasting glucose, systolic blood pressure, diastolic blood pressure and LDL. In multivariate regression analyses, triglyceride level (P=0.04) remained a significant determinant of RH

SUBMITTER: Fitch KV 

PROVIDER: S-EPMC3146552 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature