Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC3146624 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Chen Jingzhou J Shi Yi Y Li Ziyu Z Yu Hui H Han Yu Y Wang Xiaojian X Sun Kai K Yang Tao T Lou Kejia K Song Yan Y Zhang Yinhui Y Zhen Yisong Y Zhang Guiguo G Hu Ying Y Ji Jiafu J Hui Rutai R
Molecular medicine (Cambridge, Mass.) 20110302 7-8
The IC53 gene was reported to be upregulated in the colon adenocarcinoma cell line SW480. Here, we show that the expression level of IC53 is positively correlated with the grade and depth of invasion in adenocarcinoma of the colon. Injection of IC53 stably transfected HCT-116 cells into athymic nude mice promoted tumor growth. Furthermore, overexpression of IC53 increased cell invasive growth, which could be dramatically prevented by knocking down IC53 with siRNA. The effects of IC53 on cell-inv ...[more]