Ontology highlight
ABSTRACT:
SUBMITTER: Rousaki A
PROVIDER: S-EPMC3146629 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Rousaki Aikaterini A Miyata Yoshinari Y Jinwal Umesh K UK Dickey Chad A CA Gestwicki Jason E JE Zuiderweg Erik R P ER
Journal of molecular biology 20110625 3
Hsp70 (heat shock protein 70 kDa) chaperones are key to cellular protein homeostasis. However, they also have the ability to inhibit tumor apoptosis and contribute to aberrant accumulation of hyperphosphorylated tau in neuronal cells affected by tauopathies, including Alzheimer's disease. Hence, Hsp70 chaperones are increasingly becoming identified as targets for therapeutic intervention in these widely abundant diseases. Hsp70 proteins are allosteric machines and offer, besides classical active ...[more]