Ontology highlight
ABSTRACT:
SUBMITTER: Qi J
PROVIDER: S-EPMC3147184 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Qi Jianjun J Virga Kristopher G KG Das Sourav S Zhao Ying Y Yun Mi-Kyung MK White Stephen W SW Lee Richard E RE
Bioorganic & medicinal chemistry 20101215 3
The increasing emergence of resistant bacteria drives us to design and develop new antimicrobial agents. Pursuant to that goal, a new targeting approach of the dihydropteroate synthase enzyme, which serves as the site of action for the sulfonamide class of antimicrobial agents, is being explored. Using structural information, a new class of transition state mimics has been designed and synthesized that have the capacity to bind to the pterin, phosphate and para-amino binding sites. The design, s ...[more]