Ontology highlight
ABSTRACT:
SUBMITTER: Nadeau OW
PROVIDER: S-EPMC3147251 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Nadeau Owen W OW Liu Weiya W Boulatnikov Igor G IG Sage Jessica M JM Peters Jennifer L JL Carlson Gerald M GM
Biochemistry 20100801 31
Phosphorylase kinase (PhK), an (alphabetagammadelta)(4) complex, stimulates energy production from glycogen in the cascade activation of glycogenolysis. Its large homologous alpha and beta subunits regulate the activity of the catalytic gamma subunit and account for 81% of PhK's mass. Both subunits are thought to be multidomain structures, and recent predictions based on their sequences suggest the presence of potentially functional glucoamylase (GH15)-like domains near their amino termini. We p ...[more]