Importance of a hydrophobic pocket for peptide binding in lactococcal OppA.
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ABSTRACT:
SUBMITTER: Berntsson RP
PROVIDER: S-EPMC3147668 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
Importance of a hydrophobic pocket for peptide binding in lactococcal OppA.
Berntsson Ronnie P-A RP Thunnissen Andy-Mark W H AM Poolman Bert B Slotboom Dirk-Jan DJ
Journal of bacteriology 20110610 16
Lactococcal oligopeptide-binding protein A (OppA) binds peptides with widely varied lengths and sequences. We previously hypothesized that a hydrophobic pocket in OppA preferentially binds a hydrophobic peptide side chain and thus determines its binding register. Two crystal structures of OppA with different nonapeptides now indeed show binding in different registers. ...[more]
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