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Genome sequence of Streptomyces sp. strain Tu6071.

ABSTRACT: Streptomyces sp. Tü6071 is a soil-dwelling bacterium which has a highly active isoprenoid biosynthesis. Isoprenoids are important precursors for biopharmaceutical molecules such as antibiotics or anticancer agents, e.g., landomycin. Streptomyces sp. Tü6071 produces the industrially important terpene glycosides phenalinolactones, which have antibacterial activity against several Gram-positive bacteria. The availability of the genome sequence of Streptomyces sp. Tü6071 allows for understanding the biosynthesis of these pharmaceutical molecules and will facilitate rational genome modification to improve industrial use.

SUBMITTER: Erxleben A 

PROVIDER: S-EPMC3147684 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Genome sequence of Streptomyces sp. strain Tü6071.

Erxleben Anika A   Wunsch-Palasis Julia J   Grüning Björn A BA   Luzhetska Marta M   Bechthold Andreas A   Günther Stefan S  

Journal of bacteriology 20110624 16

Streptomyces sp. Tü6071 is a soil-dwelling bacterium which has a highly active isoprenoid biosynthesis. Isoprenoids are important precursors for biopharmaceutical molecules such as antibiotics or anticancer agents, e.g., landomycin. Streptomyces sp. Tü6071 produces the industrially important terpene glycosides phenalinolactones, which have antibacterial activity against several Gram-positive bacteria. The availability of the genome sequence of Streptomyces sp. Tü6071 allows for understanding the  ...[more]

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