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Fatal invasive infection with fungemia due to Microascus cirrosus after heart and lung transplantation in a patient with cystic fibrosis.


ABSTRACT: Scopulariopsis species are rarely but increasingly recognized as opportunistic pathogens in immunocompromised patients. We report on a patient suffering from cystic fibrosis who developed disseminated fungal infection due to a rare Scopulariopsis species, Microascus cirrosus, after heart and lung transplantation. Despite antifungal combination therapy with voriconazole and caspofungin, the patient died 4 weeks after transplantation. Diagnostic difficulties and optimal management of disseminated Scopulariopsis/Microascus infections are discussed.

SUBMITTER: Miossec C 

PROVIDER: S-EPMC3147864 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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Fatal invasive infection with fungemia due to Microascus cirrosus after heart and lung transplantation in a patient with cystic fibrosis.

Miossec Charline C   Morio Florent F   Lepoivre Thierry T   Le Pape Patrice P   Garcia-Hermoso Dea D   Gay-Andrieu Françoise F   Haloun Alain A   Treilhaud Michele M   Leclair François F   Miegeville Michel M  

Journal of clinical microbiology 20110504 7


Scopulariopsis species are rarely but increasingly recognized as opportunistic pathogens in immunocompromised patients. We report on a patient suffering from cystic fibrosis who developed disseminated fungal infection due to a rare Scopulariopsis species, Microascus cirrosus, after heart and lung transplantation. Despite antifungal combination therapy with voriconazole and caspofungin, the patient died 4 weeks after transplantation. Diagnostic difficulties and optimal management of disseminated  ...[more]

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