Ontology highlight
ABSTRACT:
SUBMITTER: Nagel CH
PROVIDER: S-EPMC3147933 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Journal of virology 20110601 15
Herpes simplex virus (HSV) immediate-early protein ICP0 is a transcriptional activator with E3 ubiquitin ligase activity that induces the degradation of ND10 proteins, including the promyelocytic leukemia protein (PML) and Sp100. Moreover, ICP0 has a role in the derepression of viral genomes and in the modulation of the host interferon response to virus infection. Here, we report that ICP0 interacts with SIAH-1, a cellular E3 ubiquitin ligase that is involved in multiple cellular pathways and is ...[more]