Ontology highlight
ABSTRACT:
SUBMITTER: Porichis F
PROVIDER: S-EPMC3148173 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Porichis Filippos F Kwon Douglas S DS Zupkosky Jennifer J Tighe Daniel P DP McMullen Ashley A Brockman Mark A MA Pavlik David F DF Rodriguez-Garcia Marta M Pereyra Florencia F Freeman Gordon J GJ Kavanagh Daniel G DG Kaufmann Daniel E DE
Blood 20110607 4
Defining the T helper functions impaired by programmed death-1 (PD-1) is crucial for understanding its role in defective HIV control and determining the therapeutic potential of targeting this inhibitory pathway. We describe here the relationships among disease stage, levels of PD-1 expression, and reversibility of CD4 T-cell impairment. PD-L1 blockade in vitro enhanced HIV-specific production of Th0 (IL-2), Th1 (IFN-γ), Th2 (IL-13), and TFH (IL-21) cytokines by CD4 T cells. PD-L1 blockade cause ...[more]