Ontology highlight
ABSTRACT:
SUBMITTER: Beck LH
PROVIDER: S-EPMC3148709 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Beck Laurence H LH Fervenza Fernando C FC Beck David M DM Bonegio Ramon G B RG Malik Fahim A FA Erickson Stephen B SB Cosio Fernando G FG Cattran Daniel C DC Salant David J DJ
Journal of the American Society of Nephrology : JASN 20110722 8
Autoantibodies to the M-type phospholipase A(2) receptor (PLA(2)R) are sensitive and specific for idiopathic membranous nephropathy. The anti-B cell agent rituximab is a promising therapy for this disease, but biomarkers of early response to treatment currently do not exist. Here, we investigated whether levels of anti-PLA(2)R correlate with the immunological activity of membranous nephropathy, potentially exhibiting a more rapid response to treatment than clinical parameters such as proteinuria ...[more]