Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC3149178 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Zhang Hongwei H Yang Bin B Mu Xin X Ahmed Seemin Seher SS Su Qin Q He Ran R Wang Hongyan H Mueller Christian C Sena-Esteves Miguel M Brown Robert R Xu Zuoshang Z Gao Guangping G
Molecular therapy : the journal of the American Society of Gene Therapy 20110524 8
Noninvasive systemic gene delivery to the central nervous system (CNS) has largely been impeded by the blood-brain barrier (BBB). Recent studies documented widespread CNS gene transfer after intravascular delivery of recombinant adeno-associated virus 9 (rAAV9). To investigate alternative and possibly more potent rAAV vectors for systemic gene delivery across the BBB, we systematically evaluated the CNS gene transfer properties of nine different rAAVEGFP vectors after intravascular infusion in n ...[more]