Unknown

Dataset Information

0

NMR structure of the Bordetella bronchiseptica protein NP_888769.1 establishes a new phage-related protein family PF13554.


ABSTRACT: The solution structure of the hypothetical phage-related protein NP_888769.1 from the Gram-negative bacterium Bordetella bronchoseptica contains a well-structured core comprising a five-stranded, antiparallel ?-sheet packed on one side against two ?-helices and a short ?-hairpin with three flexibly disordered loops extending from the central ?-sheet. A homology search with the software DALI identified two Protein Data Bank deposits with Z-scores > 8, where both of these proteins have less than 8% sequence identity relative to NP_888769.1, and one has been functionally annotated as a lambda phage tail terminator protein. A sequence-homology analysis then confirmed that NP_888769.1 represents the first three-dimensional structural representative of a new protein family that was previously predicted by the Joint Center for Structural Genomics, which includes so far about 20 prophage proteins encoded in bacterial genomes.

SUBMITTER: Atia-tul-Wahab 

PROVIDER: S-EPMC3149187 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

NMR structure of the Bordetella bronchiseptica protein NP_888769.1 establishes a new phage-related protein family PF13554.

Atia-tul-Wahab   Serrano Pedro P   Geralt Michael M   Wüthrich Kurt K  

Protein science : a publication of the Protein Society 20110614 7


The solution structure of the hypothetical phage-related protein NP_888769.1 from the Gram-negative bacterium Bordetella bronchoseptica contains a well-structured core comprising a five-stranded, antiparallel β-sheet packed on one side against two α-helices and a short β-hairpin with three flexibly disordered loops extending from the central β-sheet. A homology search with the software DALI identified two Protein Data Bank deposits with Z-scores > 8, where both of these proteins have less than 8  ...[more]

Similar Datasets

| S-EPMC3302436 | biostudies-literature
| S-EPMC8471281 | biostudies-literature
| S-EPMC3567102 | biostudies-literature
2020-10-27 | GSE145049 | GEO
| S-EPMC4115252 | biostudies-literature
| S-EPMC98445 | biostudies-literature
| S-EPMC10466264 | biostudies-literature
| S-EPMC176585 | biostudies-other
| S-EPMC6070651 | biostudies-literature
| S-EPMC3372540 | biostudies-literature