Ontology highlight
ABSTRACT:
SUBMITTER: Ter-Minassian M
PROVIDER: S-EPMC3149206 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Ter-Minassian Monica M Wang Zhaoxi Z Asomaning Kofi K Wu Michael C MC Liu Chen-Yu CY Paulus Jessica K JK Liu Geoffrey G Bradbury Penelope A PA Zhai Rihong R Su Li L Frauenhoffer Christine S CS Hooshmand Susanne M SM De Vivo Immaculata I Lin Xihong X Christiani David C DC Kulke Matthew H MH
Carcinogenesis 20110523 8
Genetic risk factors for sporadic neuroendocrine tumors (NET) are poorly understood. We tested risk associations in patients with sporadic NET and non-cancer controls, using a custom array containing 1536 single-nucleotide polymorphisms (SNPs) in 355 candidate genes. We identified 18 SNPs associated with NET risk at a P-value <0.01 in a discovery set of 261 cases and 319 controls. Two of these SNPs were found to be significantly associated with NET risk in an independent replication set of 235 c ...[more]