Ontology highlight
ABSTRACT:
SUBMITTER: Hollander MC
PROVIDER: S-EPMC3149208 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Hollander M Christine MC Zhou Xin X Maier Colleen R CR Patterson Andrew D AD Ding Xinxin X Dennis Phillip A PA
Carcinogenesis 20110530 8
Lung tumors from smokers as well as lung tumors from mice exposed to tobacco carcinogens such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), often carry mutations in K-ras, which activates downstream-signaling pathways such as PI3K/AKT/mTOR pathway. Mice with genetic deletion of one of three isoforms of AKT were used to investigate the role of AKT in mutant K-ras-induced lung tumorigenesis in mice. Although deletion of Akt1 or Akt2 decreased NNK-induced lung tumor formation by 90%, del ...[more]