Ontology highlight
ABSTRACT:
SUBMITTER: Eliades A
PROVIDER: S-EPMC3149354 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Eliades Alexia A Papadantonakis Nikolaos N Bhupatiraju Ajoy A Burridge Kelley A KA Johnston-Cox Hillary A HA Migliaccio Anna Rita AR Crispino John D JD Lucero Hector A HA Trackman Philip C PC Ravid Katya K
The Journal of biological chemistry 20110610 31
Lysyl oxidase (LOX), a matrix cross-linking protein, is known to be selectively expressed and to enhance a fibrotic phenotype. A recent study of ours showed that LOX oxidizes the PDGF receptor-β (PDGFR-β), leading to amplified downstream signaling. Here, we examined the expression and functions of LOX in megakaryocytes (MKs), the platelet precursors. Cells committed to the MK lineage undergo mitotic proliferation to yield diploid cells, followed by endomitosis and acquisition of polyploidy. Intr ...[more]