Ontology highlight
ABSTRACT:
SUBMITTER: Shin SB
PROVIDER: S-EPMC3149976 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Shin Sung Bin Y SB Almeida Ramiro D RD Gerona-Navarro Guillermo G Bracken Clay C Jaffrey Samie R SR
Chemistry & biology 20101101 11
Many molecules that could manipulate cellular function are not practical due to their large size and concomitant undesirable pharmocokinetic properties. Here, we describe a bioorthogonal, highly stable boronate ester (HiSBE) synthesis and use this reaction to synthesize a biologically active molecule from smaller precursors in a physiological context. The rapid rate of HiSBE synthesis suggests that it may be useful for assembling a wide variety of biologically active molecules in physiological s ...[more]