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Integration and visualization of host-pathogen data related to infectious diseases.


ABSTRACT:

Motivation

Infectious disease research is generating an increasing amount of disparate data on pathogenic systems. There is a growing need for resources that effectively integrate, analyze, deliver and visualize these data, both to improve our understanding of infectious diseases and to facilitate the development of strategies for disease control and prevention.

Results

We have developed Disease View, an online host-pathogen resource that enables infectious disease-centric access, analysis and visualization of host-pathogen interactions. In this resource, we associate infectious diseases with corresponding pathogens, provide information on pathogens, pathogen virulence genes and the genetic and chemical evidences for the human genes that are associated with the diseases. We also deliver the relationships between pathogens, genes and diseases in an interactive graph and provide the geolocation reports of associated diseases around the globe in real time. Unlike many other resources, we have applied an iterative, user-centered design process to the entire resource development, including data acquisition, analysis and visualization.

Availability and implementation

Freely available at http://www.patricbrc.org; all major web browsers supported.

Contact

cmao@vbi.vt.edu

Supplementary information

Supplementary data are available at Bioinformatics online.

SUBMITTER: Driscoll T 

PROVIDER: S-EPMC3150046 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Publications

Integration and visualization of host-pathogen data related to infectious diseases.

Driscoll Timothy T   Gabbard Joseph L JL   Mao Chunhong C   Dalay Oral O   Shukla Maulik M   Freifeld Clark C CC   Hoen Anne Gatewood AG   Brownstein John S JS   Sobral Bruno W BW  

Bioinformatics (Oxford, England) 20110627 16


<h4>Motivation</h4>Infectious disease research is generating an increasing amount of disparate data on pathogenic systems. There is a growing need for resources that effectively integrate, analyze, deliver and visualize these data, both to improve our understanding of infectious diseases and to facilitate the development of strategies for disease control and prevention.<h4>Results</h4>We have developed Disease View, an online host-pathogen resource that enables infectious disease-centric access,  ...[more]

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