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B-cell depletion therapy in systemic sclerosis: experimental rationale and update on clinical evidence.


ABSTRACT: Systemic sclerosis (SSc) is a systemic rheumatic disease with poor prognosis since therapeutic options are limited. Recent evidence from animal models suggests that B-cells may be actively involved in the fibrotic process. B-cells from tight skin mice, an animal model of scleroderma, display a "hyperresponsive" phenotype; treatment with rituximab (RTX) significantly attenuates skin fibrosis in this animal model. In humans, B-cell infiltration is a prominent finding in most lung biopsies obtained from patients with SSc-associated interstitial lung disease. Several open label studies have assessed the clinical efficacy of RTX in SSc. In most patients skin fibrosis improved; lung function either improved or remained stable. Definite conclusions regarding the clinical efficacy of RTX in SSc cannot be drawn but further exploration with a multicenter, randomized study is warranted.

SUBMITTER: Daoussis D 

PROVIDER: S-EPMC3150146 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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B-cell depletion therapy in systemic sclerosis: experimental rationale and update on clinical evidence.

Daoussis Dimitrios D   Liossis Stamatis-Nick C SN   Yiannopoulos Georgios G   Andonopoulos Andrew P AP  

International journal of rheumatology 20110803


Systemic sclerosis (SSc) is a systemic rheumatic disease with poor prognosis since therapeutic options are limited. Recent evidence from animal models suggests that B-cells may be actively involved in the fibrotic process. B-cells from tight skin mice, an animal model of scleroderma, display a "hyperresponsive" phenotype; treatment with rituximab (RTX) significantly attenuates skin fibrosis in this animal model. In humans, B-cell infiltration is a prominent finding in most lung biopsies obtained  ...[more]

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