Ontology highlight
ABSTRACT:
SUBMITTER: Daoussis D
PROVIDER: S-EPMC3150146 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Daoussis Dimitrios D Liossis Stamatis-Nick C SN Yiannopoulos Georgios G Andonopoulos Andrew P AP
International journal of rheumatology 20110803
Systemic sclerosis (SSc) is a systemic rheumatic disease with poor prognosis since therapeutic options are limited. Recent evidence from animal models suggests that B-cells may be actively involved in the fibrotic process. B-cells from tight skin mice, an animal model of scleroderma, display a "hyperresponsive" phenotype; treatment with rituximab (RTX) significantly attenuates skin fibrosis in this animal model. In humans, B-cell infiltration is a prominent finding in most lung biopsies obtained ...[more]