The effects of cognitive therapy versus 'treatment as usual' in patients with major depressive disorder.

ABSTRACT:

Background

Major depressive disorder afflicts an estimated 17% of individuals during their lifetimes at tremendous suffering and costs. Cognitive therapy may be an effective treatment option for major depressive disorder, but the effects have only had limited assessment in systematic reviews.

Methods/principal findings

Cochrane systematic review methodology, with meta-analyses and trial sequential analyses of randomized trials, are comparing the effects of cognitive therapy versus 'treatment as usual' for major depressive disorder. To be included the participants had to be older than 17 years with a primary diagnosis of major depressive disorder. Altogether, we included eight trials randomizing a total of 719 participants. All eight trials had high risk of bias. Four trials

SUBMITTER: Jakobsen JC 

PROVIDER: S-EPMC3150380 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature