Ontology highlight
ABSTRACT:
SUBMITTER: Devine SM
PROVIDER: S-EPMC3150599 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Devine Steven M SM Carter Shelly S Soiffer Robert J RJ Pasquini Marcelo C MC Hari Parameswaran N PN Stein Anthony A Lazarus Hillard M HM Linker Charles C Stadtmauer Edward A EA Alyea Edwin P EP Keever-Taylor Carolyn A CA O'Reilly Richard J RJ
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20110212 9
Graft-versus-host disease (GVHD) is most effectively prevented by ex vivo T cell depletion (TCD) of the allograft, but its role in the treatment of patients undergoing allogeneic hematopoietic cell transplantation (HCT) for acute myelogenous leukemia (AML) in complete remission (CR) remains unclear. We performed a phase 2 single-arm multicenter study to evaluate the role of TCD in AML patients in CR1 or CR2 up to age 65 years. The primary objective was to achieve a disease-free survival (DFS) ra ...[more]