Ontology highlight
ABSTRACT:
SUBMITTER: Acehan D
PROVIDER: S-EPMC3150712 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Acehan Devrim D Malhotra Ashim A Xu Yang Y Ren Mindong M Stokes David L DL Schlame Michael M
Biophysical journal 20110501 9
F(1)F(0) ATP synthase forms dimers that tend to assemble into large supramolecular structures. We show that the presence of cardiolipin is critical for the degree of oligomerization and the degree of order in these ATP synthase assemblies. This conclusion was drawn from the statistical analysis of cryoelectron tomograms of cristae vesicles isolated from Drosophila flight-muscle mitochondria, which are very rich in ATP synthase. Our study included a wild-type control, a cardiolipin synthase mutan ...[more]