Ontology highlight
ABSTRACT:
SUBMITTER: Olzmann JA
PROVIDER: S-EPMC3151032 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Olzmann James A JA Kopito Ron R RR
The Journal of biological chemistry 20110621 32
Proteins that fail to fold or assemble in the endoplasmic reticulum (ER) are destroyed by cytoplasmic proteasomes through a process known as ER-associated degradation. Substrates of this pathway are initially sequestered within the ER lumen and must therefore be dislocated across the ER membrane to be degraded. It has been proposed that generation of bicellar structures during lipid droplet formation may provide an "escape hatch" through which misfolded proteins, toxins, and viruses can exit the ...[more]