Ontology highlight
ABSTRACT:
SUBMITTER: Xu M
PROVIDER: S-EPMC3151056 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Xu Mo M Joo Hyoe-Jin HJ Paik Young-Ki YK
The Journal of biological chemistry 20110622 32
The lipid-binding protein (LBP) family is conserved from Caenorhabditis elegans to mammals and essential for fatty acid homeostasis. RNAi-mediated knockdown of nine C. elegans lbp family members revealed that lbp-5 regulates fat accumulation. C. elegans LBP-5 bound directly to various fatty acids with varying affinities. lbp-5 expression in nhr-49(nr2041) worms was much lower than in N2 worms. Nhr-49 transcriptional activity also decreased with lbp-5 deletion, suggesting that they may work toget ...[more]