Ontology highlight
ABSTRACT:
SUBMITTER: Luo K
PROVIDER: S-EPMC3151064 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Luo Kuntian K Yuan Jian J Lou Zhenkun Z
The Journal of biological chemistry 20110624 32
Mediator of DNA damage checkpoint 1 (MDC1) plays an important role in the DNA damage response (DDR). MDC1 functions as a mediator protein and binds multiple proteins involved in different aspects of the DDR. However, little is know about the organization of MDC1 complexes. Here we show that ataxia telangiectasia, mutated (ATM) phosphorylates MDC1 at Thr-98 following DNA damage, which promotes its oligomerization. Oligomerization of MDC1 is important for the accumulation of MDC1 complex at the si ...[more]