Ontology highlight
ABSTRACT:
SUBMITTER: Goble AM
PROVIDER: S-EPMC3151671 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Biochemistry 20110706 30
Four proteins from NCBI cog1816, previously annotated as adenosine deaminases, have been subjected to structural and functional characterization. Pa0148 (Pseudomonas aeruginosa PAO1), AAur1117 (Arthrobacter aurescens TC1), Sgx9403e, and Sgx9403g have been purified and their substrate profiles determined. Adenosine is not a substrate for any of these enzymes. All of these proteins will deaminate adenine to produce hypoxanthine with k(cat)/K(m) values that exceed 10(5) M(-1) s(-1). These enzymes w ...[more]