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1-[(3-Chloro-phen-yl)(morpholin-4-yl)-meth-yl]naphthalen-2-ol.

ABSTRACT: In the title compound, C(21)H(20)ClNO(2), the dihedral angle between the naphthyl-ene ring system and the phenyl ring is 77.86 (15)°. The morpholine ring adopts a chair conformation. The hydroxyl group is involved in intra-molecular O-H⋯N hydrogen bonding. A weak inter-molecular C-H⋯π inter-action is present in the crystal structure.

SUBMITTER: Shu LJ

PROVIDER: S-EPMC3151918 | biostudies-literature |

REPOSITORIES: biostudies-literature

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1-[(4-Bromo-phen-yl)(morpholin-4-yl)meth-yl]naphthalen-2-ol.

Project description:The title compound, C(21)H(20)BrNO(2), was obtained from a condensation reaction of 4-bromo-benzaldehyde, 2-naphthol and morpholine. The mol-ecular conformation is stabilized by an intra-molecular O-H?N hydrogen bond, closing a six-membered ring. The dihedral angle between the naphthalene ring system and the benzene ring is 76.72?(8)°. In addition to the intra-molecular hydrogen bond, the O-H groups of centrosymmetrically related mol-ecules form short inter-molecular H?O contacts of 2.59?Å. These mol-ecules are also linked by pairs of C-H?O inter-actions, generating an R(2) (2)(14) motif.

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1-[Amino-(4-chloro-phen-yl)meth-yl]-6-bromo-naphthalen-2-ol.

Project description:In the title compound, C(17)H(13)BrClNO, the dihedral angle between the naphthol ring system and the chloro-benzene ring is 76.59?(11)°. This twisted conformation is supported by an intra-molecular O-H?N hydrogen bond. In the crystal, [100] chains arise, with adjacent mol-ecules linked by an N-H?O hydrogen bond, a C-H?? inter-action and an aromatic ?-? stacking contact [centroid-to-centroid separation = 3.783?(2)?Å]. Weak C-H?O inter-actions also occur.

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1-[(4-Bromo-phen-yl)(morpholin-4-yl)-meth-yl]naphthalen-2-ol.

Project description:The title compound, C(21)H(20)BrNO(2), was obtained via a one-pot synthesis from the reaction of 4-bromo-benzaldehyde, 2-naphthol and morpholine. In the asymmetric unit, there are four mol-ecules with similar structures. The morpholine ring adopts a chair conformation, and the hy-droxy group links with the morpholine via an intra-molecular O-H?N hydrogen bond. The bromo-phenyl ring is approximately perpendicular to the mean pane of the naphthalene system at dihedral angles of 76.7?(3), 81.4?(3), 79.7?(3) and 84.5?(3)° in the four independent mol-ecules. Weak C-H?O hydrogen bonds are observed in the crystal.

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7-[(Morpholin-4-yl)(phen-yl)meth-yl]quinolin-8-ol.

Project description:In the title compound, C20H20N2O2, the quinoline ring system makes dihedral angles of 81.05?(4) and 61.16?(5)° with the mean planes of the benzene and morpholine rings, respectively; the mean planes of the latter two rings make a dihedral angle of 83.59?(4)°. In the crystal, pairs of O-H?N hydrogen bonds link neighbouring mol-ecules related by a twofold rotation axis, generating R2(2)(10) motifs.

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Crystal structure of 1-{(E)-[(3,4-di-chloro-phen-yl)imino]-meth-yl}naphthalen-2-ol.

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Project description:In the title compound, C(19)H(19)NO, the dihedral angle between the naphthyl ring system and the phenyl ring is 79.83?(6)°. An intra-molecular O-H?N hydrogen bond, together with van der Waals inter-actions, stabilizes the mol-ecular conformation.

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1-[(Butyl-amino)(phen-yl)meth-yl]naphthalen-2-ol.

Project description:In the title compound, C(21)H(23)NO, obtained via a one-pot synthesis, an intra-molecular O-H?N hydrogen bond stabilizes the mol-ecular conformation. The dihedral angle between the fused ring system and the phenyl ring is 78.27?(5)°. The crystal packing is characterized by helical chains of mol-ecules linked by C-H?O hydrogen bonds.

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Project description:In the title mol-ecule, C(17)H(12)INO, the dihedral angle between the naphthaldeyde plane and the 3-iodo-aniline plane is20.07?(13)°. It exists in the solid state as an enol-imine tautomer with a strong intra-molecular O-H?N hydrogen bond.

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1-[(2-Methyl-piperidin-1-yl)(phen-yl)meth-yl]naphthalen-2-ol.

Project description:In the title compound, C(23)H(25)NO, an intra-molecular O-H?N hydrogen bond defines the mol-ecular conformation; the naphthol mean plane and the benzene ring form a dihedral angle of 75.8?(2)°. The piperidine ring adopts a chair conformation. The crystal packing exhibits no short inter-molecular contacts.

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1-{(E)-[4-Bromo-2-(trifluoro-meth-oxy)phen-yl]imino-meth-yl}naphthalen-2-ol.

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