Ontology highlight
ABSTRACT:
SUBMITTER: Yin Y
PROVIDER: S-EPMC3152482 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Yin Yong Y He Xiao X Szewczyk Paul P Nguyen That T Chang Geoffrey G
Science (New York, N.Y.) 20060501 5774
EmrD is a multidrug transporter from the Major Facilitator Superfamily that expels amphipathic compounds across the inner membrane of Escherichia coli. Here, we report the x-ray structure of EmrD determined to a resolution of 3.5 angstroms. The structure reveals an interior that is composed mostly of hydrophobic residues, which is consistent with its role transporting amphipathic molecules. Two long loops extend into the inner leaflet side of the cell membrane. This region can serve to recognize ...[more]