Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-xL/Bcl-2 in Mcl-1-expressing myeloma cells.
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ABSTRACT:
SUBMITTER: Morales AA
PROVIDER: S-EPMC3152498 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
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Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-xL/Bcl-2 in Mcl-1-expressing myeloma cells.
Morales Alejo A AA Kurtoglu Metin M Matulis Shannon M SM Liu Jiangxia J Siefker David D Gutman Delia M DM Kaufman Jonathan L JL Lee Kelvin P KP Lonial Sagar S Boise Lawrence H LH
Blood 20110609 5
Dependence on Bcl-2 proteins is a common feature of cancer cells and provides a therapeutic opportunity. ABT-737 is an antagonist of antiapoptotic Bcl-2 proteins and therefore is a good predictor of Bcl-x(L)/Bcl-2 dependence. Surprisingly, analysis of Mcl-1-dependent multiple myeloma cell lines revealed codependence on Bcl-2/Bcl-x(L) in half the cells tested. Codependence is not predicted by the expression level of antiapoptotic proteins, rather through interactions with Bim. Consistent with the ...[more]
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