Ontology highlight
ABSTRACT:
SUBMITTER: Song Y
PROVIDER: S-EPMC3152605 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Song Ying Y Endepols Stefan S Klemann Nicole N Richter Dania D Matuschka Franz-Rainer FR Shih Ching-Hua CH Nachman Michael W MW Kohn Michael H MH
Current biology : CB 20110721 15
Polymorphisms in the vitamin K 2,3-epoxide reductase subcomponent 1 (vkorc1) of house mice (Mus musculus domesticus) can cause resistance to anticoagulant rodenticides such as warfarin [1-3]. Here we show that resistant house mice can also originate from selection on vkorc1 polymorphisms acquired from the Algerian mouse (M. spretus) through introgressive hybridization. We report on a polymorphic introgressed genomic region in European M. m. domesticus that stems from M. spretus, spans >10 Mb on ...[more]