Ontology highlight
ABSTRACT:
SUBMITTER: Kyttaris VC
PROVIDER: S-EPMC3153363 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Methods in molecular biology (Clifton, N.J.) 20100101
Systemic lupus erythematosus (SLE) is a disease characterized by inappropriate response to self-antigens. Genetic, environmental and hormonal factors are believed to contribute to the development of the disease. We think of SLE pathogenesis as occurring in three phases of variable duration. A series of regulatory failures during the ontogeny of the immune system lead to the emergence of auto-reactive clones and the production of auto-antibodies (phase I). As the immune response to self-antigens ...[more]