Ontology highlight
ABSTRACT:
SUBMITTER: Flandin P
PROVIDER: S-EPMC3153409 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Flandin Pierre P Zhao Yangu Y Vogt Daniel D Jeong Juhee J Long Jason J Potter Gregory G Westphal Heiner H Rubenstein John L R JL
Neuron 20110601 5
Lhx6 and Lhx8 transcription factor coexpression in early-born MGE neurons is required to induce neuronal Shh expression. We provide evidence that these transcription factors regulate expression of a Shh enhancer in MGE neurons. Lhx6 and Lhx8 are also required to prevent Nkx2-1 expression in a subset of pallial interneurons. Shh function in early-born MGE neurons was determined by genetically eliminating Shh expression in the MGE mantle zone (MZ). This mutant had reduced SHH signaling in the over ...[more]