Unknown

Dataset Information

0

Neuropeptide-S (NPS) receptor genotype modulates basolateral amygdala responsiveness to aversive stimuli.


ABSTRACT: Recent studies point to a role of neuropeptide-S (NPS) in the etiology of anxiety disorders. In animal models, NPS and its receptor (NPSR) were shown to be highly expressed in the amygdala, a central structure in the fear circuit, also known to be hyper-responsive in anxiety disorders. Recently, a functional polymorphism in the NPSR gene (rs324981 A/T) has been associated with panic disorder and anxiety sensitivity. However, the role of NPSR gene variation in the modulation of fear-related amygdala responsiveness remains to be clarified. In 79 healthy subjects genotyped for NPSR rs324981, amygdala responses were assessed by means of fMRI. The participants were presented with fear-relevant faces in a robust emotion-processing paradigm frequently used to study amygdala responsiveness. We observed a strong association of NPSR T-alleles with right amygdala responsiveness to fear-relevant faces. The association peak was located in the BLA. Furthermore, responsiveness to aversive stimuli within this BLA cluster predicted a participant's self-reported harm avoidance but not depression level. We conclude that NPSR genotype is associated with increased amygdala responsiveness to fear-relevant stimuli. Thereby, NPSR rs324981 apparently causes an indirect effect on anxiety-related traits and potentially contributes to the pathogenesis of anxiety disorders by shaping fear-related limbic activity.

SUBMITTER: Dannlowski U 

PROVIDER: S-EPMC3154106 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Neuropeptide-S (NPS) receptor genotype modulates basolateral amygdala responsiveness to aversive stimuli.

Dannlowski Udo U   Kugel Harald H   Franke Friederike F   Stuhrmann Anja A   Hohoff Christa C   Zwanzger Peter P   Lenzen Thomas T   Grotegerd Dominik D   Suslow Thomas T   Arolt Volker V   Heindel Walter W   Domschke Katharina K  

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110427 9


Recent studies point to a role of neuropeptide-S (NPS) in the etiology of anxiety disorders. In animal models, NPS and its receptor (NPSR) were shown to be highly expressed in the amygdala, a central structure in the fear circuit, also known to be hyper-responsive in anxiety disorders. Recently, a functional polymorphism in the NPSR gene (rs324981 A/T) has been associated with panic disorder and anxiety sensitivity. However, the role of NPSR gene variation in the modulation of fear-related amygd  ...[more]

Similar Datasets

| S-EPMC2042139 | biostudies-literature
| S-EPMC8639775 | biostudies-literature
| S-EPMC9304789 | biostudies-literature
| S-EPMC6482202 | biostudies-literature
| S-EPMC3321540 | biostudies-literature
| S-EPMC7108917 | biostudies-literature
| S-EPMC4900924 | biostudies-literature
| S-EPMC8986852 | biostudies-literature
| S-EPMC4526462 | biostudies-literature
| S-EPMC3327839 | biostudies-literature