Ontology highlight
ABSTRACT:
SUBMITTER: Dannlowski U
PROVIDER: S-EPMC3154106 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Dannlowski Udo U Kugel Harald H Franke Friederike F Stuhrmann Anja A Hohoff Christa C Zwanzger Peter P Lenzen Thomas T Grotegerd Dominik D Suslow Thomas T Arolt Volker V Heindel Walter W Domschke Katharina K
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110427 9
Recent studies point to a role of neuropeptide-S (NPS) in the etiology of anxiety disorders. In animal models, NPS and its receptor (NPSR) were shown to be highly expressed in the amygdala, a central structure in the fear circuit, also known to be hyper-responsive in anxiety disorders. Recently, a functional polymorphism in the NPSR gene (rs324981 A/T) has been associated with panic disorder and anxiety sensitivity. However, the role of NPSR gene variation in the modulation of fear-related amygd ...[more]