Ontology highlight
ABSTRACT:
SUBMITTER: Ito A
PROVIDER: S-EPMC315440 | biostudies-literature | 2000 May
REPOSITORIES: biostudies-literature
Ito A A Katoh F F Kataoka T R TR Okada M M Tsubota N N Asada H H Yoshikawa K K Maeda S S Kitamura Y Y Yamasaki H H Nojima H H
The Journal of clinical investigation 20000501 9
F10 and BL6 sublines of B16 mouse melanoma cells are metastatic after intravenous injection, but only BL6 cells are metastatic after subcutaneous injection. We found that connexin (Cx) 26 is upregulated in BL6 cells. To examine gap junction formation, we devised a coculture system, in which an opened vein segment was placed at the bottom of a culture dish and then dye-labeled melanoma cells were seeded onto it. Immunohistochemistry indicated that the vein segment preserved the integrity of the e ...[more]