Ontology highlight
ABSTRACT:
SUBMITTER: Zhao E
PROVIDER: S-EPMC3154532 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Zhao E E McNeilly Judy R JR McNeilly Alan S AS Fischer-Colbrie Reiner R Basak Ajoy A Seong Jae Young JY Trudeau Vance L VL
American journal of physiology. Endocrinology and metabolism 20110426 2
Secretoneurin (SN) is a functional secretogranin II (SgII)-derived peptide that stimulates luteinizing hormone (LH) production and its release in the goldfish. However, the effects of SN on the pituitary of mammalian species and the underlying mechanisms remain poorly understood. To study SN in mammals, we adopted the mouse LβT2 gonadotropin cell line that has characteristics consistent with normal pituitary gonadotrophs. Using radioimmunoassay and real-time RT-PCR, we demonstrated that static t ...[more]