The landscape of recombination in African Americans.
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ABSTRACT:
SUBMITTER: Hinch AG
PROVIDER: S-EPMC3154982 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
The landscape of recombination in African Americans.
Hinch Anjali G AG Tandon Arti A Patterson Nick N Song Yunli Y Rohland Nadin N Palmer Cameron D CD Chen Gary K GK Wang Kai K Buxbaum Sarah G SG Akylbekova Ermeg L EL Aldrich Melinda C MC Ambrosone Christine B CB Amos Christopher C Bandera Elisa V EV Berndt Sonja I SI Bernstein Leslie L Blot William J WJ Bock Cathryn H CH Boerwinkle Eric E Cai Qiuyin Q Caporaso Neil N Casey Graham G Cupples L Adrienne LA Deming Sandra L SL Diver W Ryan WR Divers Jasmin J Fornage Myriam M Gillanders Elizabeth M EM Glessner Joseph J Harris Curtis C CC Hu Jennifer J JJ Ingles Sue A SA Isaacs William W John Esther M EM Kao W H Linda WH Keating Brendan B Kittles Rick A RA Kolonel Laurence N LN Larkin Emma E Le Marchand Loic L McNeill Lorna H LH Millikan Robert C RC Murphy Adam A Musani Solomon S Neslund-Dudas Christine C Nyante Sarah S Papanicolaou George J GJ Press Michael F MF Psaty Bruce M BM Reiner Alex P AP Rich Stephen S SS Rodriguez-Gil Jorge L JL Rotter Jerome I JI Rybicki Benjamin A BA Schwartz Ann G AG Signorello Lisa B LB Spitz Margaret M Strom Sara S SS Thun Michael J MJ Tucker Margaret A MA Wang Zhaoming Z Wiencke John K JK Witte John S JS Wrensch Margaret M Wu Xifeng X Yamamura Yuko Y Zanetti Krista A KA Zheng Wei W Ziegler Regina G RG Zhu Xiaofeng X Redline Susan S Hirschhorn Joel N JN Henderson Brian E BE Taylor Herman A HA Price Alkes L AL Hakonarson Hakon H Chanock Stephen J SJ Haiman Christopher A CA Wilson James G JG Reich David D Myers Simon R SR
Nature 20110720 7359
Recombination, together with mutation, gives rise to genetic variation in populations. Here we leverage the recent mixture of people of African and European ancestry in the Americas to build a genetic map measuring the probability of crossing over at each position in the genome, based on about 2.1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans. At finer scales it differs significantly, and we ...[more]
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