Ontology highlight
ABSTRACT:
SUBMITTER: Pizarro TT
PROVIDER: S-EPMC3154989 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Pizarro Theresa T TT Pastorelli Luca L Bamias Giorgos G Garg Rekha R RR Reuter Brian K BK Mercado Joseph R JR Chieppa Marcello M Arseneau Kristen O KO Ley Klaus K Cominelli Fabio F
Inflammatory bowel diseases 20110506 12
The SAMP1/YitFc mouse strain represents a model of Crohn's disease (CD)-like ileitis that is ideal for investigating the pathogenesis of chronic intestinal inflammation. Different from the vast majority of animal models of colitis, the ileal-specific phenotype characteristic of SAMP1/YitFc mice occurs spontaneously, without genetic, chemical, or immunological manipulation. In addition, SAMP1/YitFc mice possess remarkable similarities to the human condition with regard to disease location, histol ...[more]