Ontology highlight
ABSTRACT:
SUBMITTER: Mosconi L
PROVIDER: S-EPMC3155000 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Mosconi Lisa L Tsui Wai W Murray John J McHugh Pauline P Li Yi Y Williams Schantel S Pirraglia Elizabeth E Glodzik Lidia L De Santi Susan S Vallabhajosula Shankar S de Leon Mony J MJ
Neurobiology of aging 20110422 3
Cognitively normal (NL) individuals with a maternal history of late-onset Alzheimer's disease (MH) show reduced brain glucose metabolism on FDG-PET as compared to those with a paternal history (PH) and those with negative family history (NH) of Alzheimer's disease (AD). This FDG-PET study investigates whether metabolic deficits in NL MH are associated with advancing maternal age at birth. Ninety-six NL individuals with FDG-PET were examined, including 36 MH, 24 PH, and 36 NH. Regional-to-whole b ...[more]