Surface-based protein binding pocket similarity.
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ABSTRACT:
SUBMITTER: Spitzer R
PROVIDER: S-EPMC3155014 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
Surface-based protein binding pocket similarity.
Spitzer Russell R Cleves Ann E AE Jain Ajay N AN
Proteins 20110718 9
Protein similarity comparisons may be made on a local or global basis and may consider sequence information or differing levels of structural information. We present a local three-dimensional method that compares protein binding site surfaces in full atomic detail. The approach is based on the morphological similarity method which has been widely applied for global comparison of small molecules. We apply the method to all-by-all comparisons two sets of human protein kinases, a very diverse set o ...[more]
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