Ontology highlight
ABSTRACT:
SUBMITTER: Lima-Fernandes E
PROVIDER: S-EPMC3155309 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Lima-Fernandes Evelyne E Enslen Hervé H Camand Emeline E Kotelevets Larissa L Boularan Cédric C Achour Lamia L Benmerah Alexandre A Gibson Lucien C D LC Baillie George S GS Pitcher Julie A JA Chastre Eric E Etienne-Manneville Sandrine S Marullo Stefano S Scott Mark G H MG
The EMBO journal 20110603 13
The tumour suppressor PTEN (phosphatase and tensin deleted on chromosome 10) regulates major cellular functions via lipid phosphatase-dependent and -independent mechanisms. Despite its fundamental pathophysiological importance, how PTEN's cellular activity is regulated has only been partially elucidated. We report that the scaffolding proteins β-arrestins (β-arrs) are important regulators of PTEN. Downstream of receptor-activated RhoA/ROCK signalling, β-arrs activate the lipid phosphatase activi ...[more]