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Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium.

ABSTRACT: OBJECTIVE:To examine genetic associations of polymorphisms in the dopamine receptor D2 (DRD2) and D3 (DRD3) genes with risk of Parkinson's disease (PD). METHODS:The study included 1325 newly diagnosed patients with PD and 1735 controls from a consortium of five North American case-control studies. We collected risk factor information by in-person or telephone interview. Six DRD2 and two DRD3 polymorphisms were genotyped using a common laboratory. Odds ratios were estimated using logistic regression. RESULTS:Among non-Hispanic whites, homozygous carriers of Taq1A DRD2 (rs1800497) polymorphism had an increased risk of PD compared to homozygous wildtype carriers (OR=1.5, 95% CI 1.0-2.3). In contrast, the direction of association for Taq1A polymorphism was opposite for African-Americans, showing an inverse association with PD risk (OR=0.10, 95% CI 0.2-0.7). Among white Hispanics who carried two alleles, the Ser9Gly DRD3 (rs6280) polymorphism was associated with a decreased risk of PD (OR=0.4, 95% CI 0.2-0.8). The inverse association of smoking with PD risk was not modified by any of the DRD2 or DRD3 polymorphisms. CONCLUSIONS:DRD2 polymorphisms are unlikely to be true disease-causing variants; however, three DRD2 polymorphisms (including Taq1A) may be in linkage disequilibrium with possible disease associated variants in the DRD2-ANKK1-NCAM1-TTC12 gene cluster.

SUBMITTER: McGuire V 

PROVIDER: S-EPMC3155471 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium.

McGuire V V   Van Den Eeden S K SK   Tanner C M CM   Kamel F F   Umbach D M DM   Marder K K   Mayeux R R   Ritz B B   Ross G W GW   Petrovitch H H   Topol B B   Popat R A RA   Costello S S   Manthripragada A D AD   Southwick A A   Myers R M RM   Nelson L M LM  

Journal of the neurological sciences 20110612 1-2

<h4>Objective</h4>To examine genetic associations of polymorphisms in the dopamine receptor D2 (DRD2) and D3 (DRD3) genes with risk of Parkinson's disease (PD).<h4>Methods</h4>The study included 1325 newly diagnosed patients with PD and 1735 controls from a consortium of five North American case-control studies. We collected risk factor information by in-person or telephone interview. Six DRD2 and two DRD3 polymorphisms were genotyped using a common laboratory. Odds ratios were estimated using l  ...[more]