Ontology highlight
ABSTRACT:
SUBMITTER: Engmann O
PROVIDER: S-EPMC3155706 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Engmann Olivia O Hortobágyi Tibor T Pidsley Ruth R Troakes Claire C Bernstein Hans-Gert HG Kreutz Michael R MR Mill Jonathan J Nikolic Margareta M Giese Karl Peter KP
Brain : a journal of neurology 20110719 Pt 8
Cyclin-dependent kinase 5 is activated by small subunits, of which p35 is the most abundant. The functions of cyclin-dependent kinase 5 signalling in cognition and cognitive disorders remains unclear. Here, we show that in schizophrenia, a disorder associated with impaired cognition, p35 expression is reduced in relevant brain regions. Additionally, the expression of septin 7 and OPA1, proteins downstream of truncated p35, is decreased in schizophrenia. Mimicking a reduction of p35 in heterozygo ...[more]