Ontology highlight
ABSTRACT:
SUBMITTER: Pollack SJ
PROVIDER: S-EPMC3155752 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Pollack Scott J SJ Beyer Kim S KS Lock Christopher C Müller Ilka I Sheppard David D Lipkin Mike M Hardick David D Blurton Peter P Leonard Philip M PM Hubbard Paul A PA Todd Daniel D Richardson Christine M CM Ahrens Thomas T Baader Manuel M Hafenbradl Doris O DO Hilyard Kate K Bürli Roland W RW
Journal of computer-aided molecular design 20110706 7
The stress-activated kinase p38α was used to evaluate a fragment-based drug discovery approach using the BioFocus fragment library. Compounds were screened by surface plasmon resonance (SPR) on a Biacore(™) T100 against p38α and two selectivity targets. A sub-set of our library was the focus of detailed follow-up analyses that included hit confirmation, affinity determination on 24 confirmed, selective hits and competition assays of these hits with respect to a known ATP binding site inhibitor. ...[more]