Ontology highlight
ABSTRACT:
SUBMITTER: Amit R
PROVIDER: S-EPMC3155781 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Amit Roee R Garcia Hernan G HG Phillips Rob R Fraser Scott E SE
Cell 20110701 1
A challenge of the synthetic biology approach is to use our understanding of a system to recreate a biological function with specific properties. We have applied this framework to bacterial enhancers, combining a driver, transcription factor binding sites, and a poised polymerase to create synthetic modular enhancers. Our findings suggest that enhancer-based transcriptional control depends critically and quantitatively on DNA looping, leading to complex regulatory effects when the enhancer casse ...[more]