Ontology highlight
ABSTRACT:
SUBMITTER: Nuth M
PROVIDER: S-EPMC3155816 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Nuth Manunya M Huang Lijuan L Saw Yih Ling YL Schormann Norbert N Chattopadhyay Debasish D Ricciardi Robert P RP
Journal of medicinal chemistry 20110419 9
Smallpox was globally eradicated 30 years ago by vaccination. The recent threat of bioterrorism demands the development of improved vaccines and novel therapeutics to effectively preclude a reemergence of smallpox. One new therapeutic target is the vaccinia poxvirus processivity complex, comprising D4 and A20 proteins that enable the viral E9 DNA polymerase to synthesize extended strands. Five compounds identified from an AlphaScreen assay designed to disrupt A20:D4 binding were shown to be effe ...[more]