High platelet count as a link between renal cachexia and cardiovascular mortality in end-stage renal disease patients.

ABSTRACT:

Background

It is not clear why cardiac or renal cachexia in chronic diseases is associated with poor cardiovascular outcomes. Platelet reactivity predisposes to thromboembolic events in the setting of atherosclerotic cardiovascular disease, which is often present in patients with end-stage renal disease (ESRD).

Objectives

We hypothesized that ESRD patients with relative thrombocytosis (platelet count >300 × 10(3)/μL) have a higher mortality rate and that this association may be related to malnutrition-inflammation cachexia syndrome (MICS).

Design

We examined the associations of 3-mo-averaged platelet counts with markers of MICS and 6-y all-cause and cardiovascular mortality (2001-2007) in a cohort of 40,797 patients who were receiving maintenance hemodialysis.

Resu

SUBMITTER: Molnar MZ 

PROVIDER: S-EPMC3155928 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature