Ontology highlight
ABSTRACT:
SUBMITTER: Jiao Y
PROVIDER: S-EPMC3155952 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Jiao Yan Y Cai Chun C Kermany Mohammad Habiby MH Yan Jian J Cai Qing Q Miller Darla D Goldowitz Daniel D Li Xinmin X Yoo Tai-June TJ Gu Weikuan W
Genes & genetic systems 20090601 3
The hallmark of age-related (presbycusis) and noise-induced hearing loss is high-frequency (> 20 kHz) hearing loss. Through a collaborative study with TMGC (Tennessee Mouse Genome Consortium), seventeen ENU-induced mouse mutation strains with high-frequency hearing loss have been identified, but affected genes are yet identified. As a first step in identifying the gene/s underlying the ENU mutations, we created a F2 population between a representative mutation strain, 118 TNE and a wild type str ...[more]