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ENU induced single mutation locus on chr 16 leads to high-frequency hearing loss in mice.


ABSTRACT: The hallmark of age-related (presbycusis) and noise-induced hearing loss is high-frequency (> 20 kHz) hearing loss. Through a collaborative study with TMGC (Tennessee Mouse Genome Consortium), seventeen ENU-induced mouse mutation strains with high-frequency hearing loss have been identified, but affected genes are yet identified. As a first step in identifying the gene/s underlying the ENU mutations, we created a F2 population between a representative mutation strain, 118 TNE and a wild type strain, CAST/EJ (CAST). Phenotypic analysis showed that there is a 3:1 ratio of segregation between normal and hearing loss in the F2 population, suggestion a single locus regulation. However, the linkage mapping identified 2 QTLs, each on chromosomes 15 and 16. Further statistical analysis of marker segregation patterns revealed that the locus on Chr 16 was ENU induced while the one on Chr 15 was derived from the parental strain, CAST.

SUBMITTER: Jiao Y 

PROVIDER: S-EPMC3155952 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

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ENU induced single mutation locus on chr 16 leads to high-frequency hearing loss in mice.

Jiao Yan Y   Cai Chun C   Kermany Mohammad Habiby MH   Yan Jian J   Cai Qing Q   Miller Darla D   Goldowitz Daniel D   Li Xinmin X   Yoo Tai-June TJ   Gu Weikuan W  

Genes & genetic systems 20090601 3


The hallmark of age-related (presbycusis) and noise-induced hearing loss is high-frequency (> 20 kHz) hearing loss. Through a collaborative study with TMGC (Tennessee Mouse Genome Consortium), seventeen ENU-induced mouse mutation strains with high-frequency hearing loss have been identified, but affected genes are yet identified. As a first step in identifying the gene/s underlying the ENU mutations, we created a F2 population between a representative mutation strain, 118 TNE and a wild type str  ...[more]

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