Ontology highlight
ABSTRACT:
SUBMITTER: Cui D
PROVIDER: S-EPMC3156030 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Cui Dongtao D Koder Ronald L RL Dutton P Leslie PL Miller Anne-Frances AF
The journal of physical chemistry. B 20110527 24
Flavins mediate a wide variety of chemical reactions in biology. To learn how one cofactor can be made to execute different reactions in different enzymes, we are developing solid-state NMR (SSNMR) to probe the flavin electronic structure, via the (15)N chemical shift tensor principal values (δ(ii)). We find that SSNMR has superior responsiveness to H-bonds, compared to solution NMR. H-bonding to a model of the flavodoxin active site produced an increase of 10 ppm in the δ(11) of N5, although no ...[more]