Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells.
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ABSTRACT:
SUBMITTER: Ando Y
PROVIDER: S-EPMC3156128 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells.
Ando Yoshinari Y Ando Yoshinari Y Tomaru Yasuhiro Y Morinaga Ayako A Burroughs Alexander Maxwell AM Kawaji Hideya H Kubosaki Atsutaka A Kimura Ryuichiro R Tagata Maiko M Ino Yoko Y Hirano Hisashi H Chiba Joe J Suzuki Harukazu H Carninci Piero P Hayashizaki Yoshihide Y
PloS one 20110815 8
Human DICER1 protein cleaves double-stranded RNA into small sizes, a crucial step in production of single-stranded RNAs which are mediating factors of cytoplasmic RNA interference. Here, we clearly demonstrate that human DICER1 protein localizes not only to the cytoplasm but also to the nucleoplasm. We also find that human DICER1 protein associates with the NUP153 protein, one component of the nuclear pore complex. This association is detected predominantly in the cytoplasm but is also clearly d ...[more]
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